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Regulation of the human transforming growth factor β type II receptor gene promoter by novel Sp1 sites

✍ Scribed by Jennings, Ron; Alsarraj, Marwan; Wright, Kenneth L; Muñoz-Antonia, Teresita

Book ID
110066050
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
319 KB
Volume
20
Category
Article
ISSN
0950-9232

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Alteration of transforming growth factor beta1 (TGF-beta1) type II receptor (RII) appears to cause unresponsiveness to TGF-beta1 in tumorigenic cells. Defect in the mononucleotide repeat sequence, i.e., poly A region of TGF-beta1RII gene has been reported to be related to replication error-positive