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Regulation of the Epstein−Barr Virus LMP1-mediated NF-kappaB Signaling Pathway by a Novel Adaptor Protein STAP-2

✍ Scribed by Osamu Ikeda; Yuichi Sekine; Teruhito Yasui; Suita Kenji Sugiyma; Kenji Oritani; Suita Akihiko Yoshimura; Tadashi Matsuda


Book ID
113539767
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
54 KB
Volume
123
Category
Article
ISSN
1090-2341

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TAB2, a Novel Adaptor Protein, Mediates
✍ Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 382 KB

The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ