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Regulation of the DNA Damage Response by p53 Cofactors

✍ Scribed by Zhang, Xiao-Peng; Liu, Feng; Wang, Wei


Book ID
118742769
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
563 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. Howe