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Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads

✍ Scribed by Sirio Dupont; Masafumi Inui; Stuart J. Newfeld

Book ID
113622976
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
512 KB
Volume
586
Category
Article
ISSN
0014-5793

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for