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Regulation of T-cell activation by the cytoskeleton

✍ Scribed by Billadeau, Daniel D.; Nolz, Jeffrey C.; Gomez, Timothy S.


Book ID
109955624
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
940 KB
Volume
7
Category
Article
ISSN
1474-1741

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T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based acti