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Regulation of T and B Cell Responses by Modulating Interactions between CD28/CTLA4 and Their Ligands, CD80 and CD86

✍ Scribed by PETER LANE


Book ID
111393327
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
498 KB
Volume
815
Category
Article
ISSN
0890-6564

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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d