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Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86

✍ Scribed by Claire N. Manzotti; Michael K. P. Liu; Fiona Burke; Laure Dussably; Yong Zheng; David M. Sansom

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
372 KB
Volume
36
Category
Article
ISSN
0014-2980

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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d