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Regulation of sugar transport in chick embryo fibroblasts and in fibroblasts transformed by a temperature-sensitive mutant of the rous sarcoma virus

✍ Scribed by Rolf F. Kletzien; James F. Perdue

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
394 KB
Volume
89
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The mode of induction of sugar transport by serum‐stimulation of growth and hexose‐starvation in chick embryo fibroblasts (CEF) has been studied using metabolic inhibitors. We have concluded from these studies that the sugar transport increases induced by serum‐stimulation are regulated by post‐transcriptional and post‐translational mechanisms while sugar transport increases induced by hexose‐starvation are regulated by a transcriptional mechanism. CEF infected with a temperature‐sensitive mutant of the Rous sarcoma virus, Ts68, and incubated at the nonpermissive temperature for transformation, 41°, retain the capacity to regulate sugar transport in a manner similar to uninfected CEF. However, Ts68‐infected CEF maintained at the permissive temperature for transformation, 37°, have lost the ability to regulate sugar transport at the post‐transcriptional and post‐translational levels.

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