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Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

✍ Scribed by Wanjin Tang; Maria Norlin

Book ID: 116292709
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 148 KB
Volume: 344
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.03.175

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## Abstract Activation of PKCδ in androgen‐dependent LNCaP prostate cancer cells leads to apoptosis via the activation of p38 MAPK and JNK cascades. We have recently shown that treatment of LNCaP cells with phorbol 12‐myristate 13‐acetate (PMA) leads to a PKCδ‐mediated autocrine release of death fa