Regulation of Signaling by Protein-Tyrosine Phosphatases: Potential Roles in the Nervous System
โ Scribed by Carlos O. Arregui; Janne Balsamo; Jack Lilien
- Book ID
- 110252012
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 61 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0364-3190
No coin nor oath required. For personal study only.
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Antigen-receptor signaling requires Src-family kinases to initiate tyrosine phosphorylation. CD45 dephosphorylates the inhibitory site in Src-family kinases before antigen-receptor engagement and thus serves to 'prime' the kinases. It has been unclear why CD45 does not also dephosphorylate 'activate