Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases
โ Scribed by Barry J. Goldstein; Faiyaz Ahmad; Wendi Ding; Pei-Ming Li; Wei-Ren Zhang
- Book ID
- 110241585
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 117 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0300-8177
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๐ SIMILAR VOLUMES
Protein-tyrosine phosphatases (PTPases) play an important role in the regulation of insulin action by dephosphorylating the active (autophosphorylated) form of the insulin receptor and attenuating its tyrosine kinase activity. PTPases can also modulate post-receptor signalling by catalyzing the deph
The regulation of tyrosine phosphorylation represents a key mechanism governing cell proliferation. In fibroblasts, inputs from both growth factor and extracellular matrix receptors are required for cell division. Triggering such receptors induces a wave of tyrosine phosphorylation on key signaling