✦ LIBER ✦

Regulation of Schwann cell function by the extracellular matrix

✍ Scribed by Michael A. Chernousov; Wei-Ming Yu; Zu-Lin Chen; David J. Carey; Sidney Strickland

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 234 KB
Volume: 56
Category: Article
ISSN: 0894-1491
DOI: 10.1002/glia.20740

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development. © 2008 Wiley‐Liss, Inc.

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