𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Myelination by Schwann cells in the absence of extracellular matrix assembly

✍ Scribed by Jewel L. Podratz; Esther H. Rodriguez; Elizabeth S. Dinonno; Anthony J. Windebank

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
419 KB
Volume
23
Category
Article
ISSN
0894-1491

No coin nor oath required. For personal study only.

✦ Synopsis

Assembly of extracellular collagen fibrils and Schwann cell basal lamina has previously been identified as a prerequisite for compact myelin formation in the peripheral nervous system. Synthesis of this extracellular matrix (ECM) in vitro required the presence of serum and ascorbic acid. Using rat embryonic dorsal root ganglion neurons and Schwann cells, we have developed a fully defined medium in which myelination occurs. In the absence of ascorbic acid, normal myelin was formed without ECM assembly. This demonstrates that although myelination and ECM assembly are usually closely linked, ECM formation is not a prerequisite for myelination in vitro.

πŸ“œ SIMILAR VOLUMES

Myelin formation by Schwann cells in the
Myelin formation by Schwann cells in the absence of Ξ²4 integrin
✍ Regula Frei; James Dowling; Stefano Carenini; Elaine Fuchs; Rudolf Martini πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 355 KB πŸ‘ 1 views

The interaction of the Schwann cell with its basal lamina has been hypothesized to be an important prerequisite for the formation of a myelin sheath in the peripheral nervous system. One possible player in this interaction is ␀4 integrin; it is up-regulated during myelin formation and, in associatio

Stimulation of extracellular matrix comp
Stimulation of extracellular matrix components in the normal brain by invading glioma cells
✍ Jo C. A. Knott; Rupavathana Mahesparan; Inmaculada Garcia-Cabrera; Berit BΓΈlge T πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 352 KB πŸ‘ 1 views

## Malignant gliomas are characterized by an extensive invasion of tumor cells into the normal brain parenchyma. A substantial amount of data indicates that cell movement in general is regulated by specific interactions between extracellular matrix components and specific cell-surface receptors. I

Prolidase activity in fibroblasts is reg
Prolidase activity in fibroblasts is regulated by interaction of extracellular matrix with cell surface integrin receptors
✍ Jerzy A. Palka; James M. Phang πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 128 KB πŸ‘ 1 views

Prolidase (EC 3.4.13.9) is a ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of C-terminal proline or hydroxyproline containing dipeptides. The enzyme plays an important role in the recycling of proline for collagen synthesis and cell growth. An increase in enzyme activity is

Absence of cell-surface annexin V is acc
Absence of cell-surface annexin V is accompanied by defective collagen matrix binding in the swarm rat chondrosarcoma
✍ Karen B. King; Susan Chubinskaya; David L. Reid; Lawrence H. Madsen; Juergen Mol πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 231 KB πŸ‘ 1 views

Annexin V has been characterized as a major collagen type II binding cell-surface component of normal chondrocytes and is also called anchorin CII in chondrogenic populations. Herein we present evidence that in vitro cultured Swarm rat chondrosarcoma cells are not capable of binding collagen type II

Expression of Hoxa-1 and Hoxb-7 is regul
Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells
✍ Anabella Srebrow; Yael Friedmann; Ali Ravanpay; Charles W. Daniel; Mina J. Bisse πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 377 KB πŸ‘ 2 views

Homeobox-containing genes encode transcriptional regulators involved in cell fate and pattern formation during embryogenesis. Recently, it has become clear that their expression in continuously developing adult tissues, as well as in tumorigenesis, may be of equal importance. In the mouse mammary gl