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Regulation of PPARα activity and expression by metformin in cardiomyocytes: Involvement of the AMP-activated protein kinase

✍ Scribed by Michael Steinmetz; Thomas Quentin; Ulrich Krause; Andrea Poppe; Christian Jux; Thomas Paul


Book ID
116983881
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
60 KB
Volume
40
Category
Article
ISSN
0022-2828

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## Abstract Brief periods of ischemia and reperfusion that precede sustained ischemia lead to a reduction in myocardial infarct size. This phenomenon, known as ischemic preconditioning, is mediated by signaling pathway(s) that is complex and yet to be fully defined. AMP‐activated kinase (AMPK) is a