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Regulation of pleiotropic drug resistance in yeast

✍ Scribed by Anna Kolaczkowska; Andre Goffeau

Book ID
119763694
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
257 KB
Volume
2
Category
Article
ISSN
1368-7646

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The network of genes which mediates multiple drug resistance in yeast includes, among others, the PDR1 gene, which encodes a putative regulator of gene expression, and PDR5, a locus whose amplification leads to resistance. We demonstrate that disruption of PDR5 causes marked hypersensitivity not onl