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Multiple or pleiotropic drug resistance in yeast

✍ Scribed by Balzi, Elisabetta; Goffeau, André

Book ID
122862620
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
638 KB
Volume
1073
Category
Article
ISSN
0304-4165

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The network of genes which mediates multiple drug resistance in yeast includes, among others, the PDR1 gene, which encodes a putative regulator of gene expression, and PDR5, a locus whose amplification leads to resistance. We demonstrate that disruption of PDR5 causes marked hypersensitivity not onl