regulation of platelet-derived growth factor (PDGF) synthesis in human astrocytes by cytokines
β Scribed by F.Ceccherini Silberstein; R. De Simone; B. Levi; F. Aloisi
- Book ID
- 116103163
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 192 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0165-5728
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Tumor cells may stimulate their own proliferation through an autocrine mechanism by simultaneously producing growth factors and growth factor receptors. We now report that numerous human tumor-derived cell lines simultaneously express the genes for platelet-derived growth factor (PDGF) A and B chain
In this study we analyzed the expression of mRNA for PDGF-B and PDGF B-type receptor (PDGFrecB) in 42 biopsy specimens from human astrocytic gliomas and other brain tumors. All gliomas expressed PDGF-B mRNA at higher levels than found in peritumoral and normal nervous tissues. Levels of PDGF-B trans