Regulation of plasminogen activator inhibitor type 1 in cultured smooth muscle cells by interleukin 1α and tumour necrosis factor-α
✍ Scribed by M. Gallicchio; J. Wojta; J.A. Hamilton; K. McGrath
- Book ID
- 114201028
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 932 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0268-9499
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The effects were examined of baicalein on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) production stimulated by interleukin-1␣ (IL-1) and tumour necrosis factor-␣ (TNF-␣) in cultured human vein umbilical endothelial cells (HUVECs). IL-1 and TNF-␣ increased
## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre