✦ LIBER ✦

Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent

✍ Scribed by Nurit Kaiser; Henry R. Bourne; Paul A. Insel; Philip Coffino

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 391 KB
Volume: 101
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041010304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cyclic AMP (cAMP) causes growth arrest in G~1~ and induction of cAMP phosphodiesterase and decrease of ornithine decarboxylase in S49 mouse lymphoma cells. Dibutyryl cAMP treatment of partially synchronized cells causes similar changes in activities of both enzymes, regardless of position in the cell cycle. This suggests that cAMP regulation of these enzymes is not mediated by growth perturbation.

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