Regulation of parathyroid hormone-related peptide production in vitro by the hypercalcemic leydig cell tumor H-500
β Scribed by Liu, B.; Goltzman, D.; Rabbani, S.A.
- Book ID
- 122937930
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 199 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0169-6009
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## Abstract To attain full biological activity, the precursor proβparathyroid hormoneβrelated peptide (ProPTHRP) must be converted to the mature peptide PTHRP. We have examined the effect of inhibiting expression of the proβhormone convertase furin in Hβ500 rat Leydig tumor cells on PTHRP productio
## Abstract Parathyroid hormoneβrelated peptide (PTHrP) is known to be an important regulator of chondrocyte differentiation in embryonic growth plates, but little is known of its role in postnatal growth plates. The present study explores the role of PTHrP in regulating postnatal chondrocyte diffe