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Regulation of p53 stability and activity in response to genotoxic stress

โœ Scribed by Michael S. Colman; Cynthia A. Afshari; J.Carl Barrett


Book ID
117768047
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
117 KB
Volume
462
Category
Article
ISSN
1383-5742

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Oxidative stress to mammalian cells causes cellular damage and triggers inducible cellular responses leading to cell death by apoptosis. In this paper, we report that p53 was required for programmed cell death induced by oxidative stress in both mouse and human cells and that p53 transactivation was