Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells
β Scribed by Fraser, M; Chan, S L; Chan, S S L; Fiscus, R R; Tsang, B K
- Book ID
- 110070282
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 544 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0950-9232
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## Abstract A p53 Cβterminal peptide (aa 361β382, p53p), fused at its Cβterminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53pβAnt), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53pβAnt mechanism of action, toxicity in var
Gonadotropins have been suggested to play a role in the development or progression of ovarian cancer, and we have previously reported the expression of luteinizing hormone/ human chorionic gonadotropin (LH/hCG) receptor in 40% of epithelial ovarian carcinomas. To examine the biological effect of LH/