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Regulation of NF-κB induction by TCR/CD28

✍ Scribed by Jing Cheng; Angela Montecalvo; Lawrence P. Kane


Book ID
107572543
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
162 KB
Volume
50
Category
Article
ISSN
0257-277X

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Induction of proliferation in primary resting T cells requires engagement of both the antigenspecific TCR and the co-stimulatory receptor CD28. Here we report that CD28 functions as an autonomous mitogenic receptor which is mobilized by TCR signaling through cytoskeletal rearrangement. Shortcutting