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The Proto-Oncogene Cot Kinase Participates in CD3/CD28 Induction of NF-κB Acting through the NF-κB-Inducing Kinase and IκB Kinases

✍ Scribed by Xin Lin; Emmett T Cunningham Jr.; Yajun Mu; Romas Geleziunas; Warner C Greene


Book ID
117722456
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
250 KB
Volume
10
Category
Article
ISSN
1074-7613

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This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of