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Regulation of neurotransmitter release by endogenous nitric oxide in striatal slices

✍ Scribed by Taleen Hanania; Kenneth M. Johnson

Book ID
114016634
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
205 KB
Volume
359
Category
Article
ISSN
0014-2999

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## Abstract Hydroxylamine (0.01–30 mM), a nitric oxide (NO) generator, produced a concentration‐dependent release of [^3^H]dopamine ([^3^H]DA) from rat striatal slices. Hemoglobin (10 ΞΌM), a NO scavenger, reduced basal [^3^H]DA release and blocked hydroxylamine (100 ΞΌM)‐stimulated [^3^H]DA efflux.