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Effect of Nitroprusside (Nitric Oxide) on Endogenous Dopamine Release from Rat Striatal Slices

✍ Scribed by Xing-Zu Zhu; Lu-Guang Luo

Book ID
118713992
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
352 KB
Volume
59
Category
Article
ISSN
0022-3042

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## Abstract Hydroxylamine (0.01–30 mM), a nitric oxide (NO) generator, produced a concentration‐dependent release of [^3^H]dopamine ([^3^H]DA) from rat striatal slices. Hemoglobin (10 ΞΌM), a NO scavenger, reduced basal [^3^H]DA release and blocked hydroxylamine (100 ΞΌM)‐stimulated [^3^H]DA efflux.