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Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts

✍ Scribed by Neil A. Turner; Karen E. Porter

Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 124 KB
Volume: 64
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.1004

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✦ Synopsis

Abstract

Cardiac fibroblasts (CF) play a key role in orchestrating the structural remodeling of the myocardium in response to injury or stress, in part through direct regulation of extracellular matrix (ECM) turnover. The matrix metalloproteinases (MMPs) are a family of over 25 zinc‐dependent proteases that together have the capacity to degrade all the protein components of the ECM. Fibroblasts are a major source of several MMPs in the heart, thereby representing a viable therapeutic target for regulating ECM turnover in cardiac pathologies characterized by adverse remodeling, such as myocardial infarction, cardiomyopathy, hypertension and heart failure. This review summarizes current knowledge on the identity and regulation of MMPs expressed by CF and discusses future directions for reducing adverse myocardial remodeling by modulating the expression and/or activity of CF‐derived MMPs. © 2012 IUBMB IUBMB Life, 2012.

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