Regulation of MDR2 p-glycoprotein expression by bile salts and cholesterol in rats and primary cultures of rat hepatocytes
β Scribed by Seema, Gupta; Stravitz, Richard T.; Pandak, William M.; Muller, Michael; Vlahcevic, Zdravko R.; Hylemon, Phillip B.
- Book ID
- 123440085
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 190 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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Mammalian liver exhibits expression of members of the family of multidrug resistance (mdr) transporters (P-glycoproteins). P-glycoprotein isoforms encoded by mdr1 genes participate in extrusion of an array of xenobiotics into the bile. Induction of mdr1b mRNA expression has been shown to occur in ra
P-glycoprotein (Pgp) is a small family of plasma membrane proteins, which are capable of transporting substrates across cell membranes. Class I and II Pgp are able to transport drugs and have been shown to mediate multidrug resistance (MDR). Class III Pgp is a long chain phospholipid transporter and