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Regulation of matrix metalloproteinase-2 in the heart by caveolin-1

โœ Scribed by A.K. Chow; J. Cena; A.F. El-Yazbi; B.D. Crawford; A. Holt; W.J. Cho; E.E. Daniel; R. Schulz


Book ID
116984820
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
48 KB
Volume
42
Category
Article
ISSN
0022-2828

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Matrix metalloproteinase-2 activation in
โœ Anne-Marie Prรฉaux; Ariane Mallat; Jeanne Tran Van Nhieu; Marie-Pia d'Ortho; Rosa ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 182 KB

Matrix metalloproteinase-2 (MMP-2) is involved in extracellular matrix remodeling. It is secreted as a proenzyme and activated by membrane type-MMPs (MT-MMP), such as MT1-MMP. In liver fibrosis, MMP-2 is highly expressed in myofibroblasts and may have a profibrogenic role. The mechanisms of its acti