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Regulation of kynurenic acid levels in the developing rat brain

✍ Scribed by R. Schwarcz; B. Poeggeler; A. Rassoulpour; G. Ceresoli-Borroni; P. S. Hodgkins


Publisher
Springer
Year
1998
Tongue
English
Weight
467 KB
Volume
14
Category
Article
ISSN
0939-4451

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πŸ“œ SIMILAR VOLUMES


Identification and measurement of kynure
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Kynurenic acid, a biologically active tryptophan metabolite, has been identified and measured in the rat brain and other organs using HPLC and GC/MS. Both the described methods required extraction of the compound in alkaline ethanol and initial purification on Dowex ion-exchange resins. The GC/MS ap

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The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy. Treatment with intracerebroventricular KYA (360 nmoles (adult dose) or 240 nmoles (prepuhescent dose))