## Abstract Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from lysine residues in both histone and nonβhistone proteins. They play a key role in the regulation of gene transcription and many other biological processes involving chromatin. Significantly, recent
Regulation of kidney development by histone deacetylases
β Scribed by Stacy L. Rosenberg; Shaowei Chen; Nathan McLaughlin; Samir S. El-Dahr
- Book ID
- 106161938
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 374 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-041X
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Acetylation of internal lysine residues of core histone N-terminal domains has been found correlatively associated with transcriptional activation in eukaryotes for more than three decades. Recent discoveries showing that several transcriptional regulators possess intrinsic histone acetyltransferase
## Abstract The C/EBPΞ΄ transcription factor is involved in the positive regulation of the intestinal epithelial cell acute phase response. C/EBPΞ΄ regulation by histone deacetylases (HDACs) during the course of inflammation remains to be determined. Our aim was to examine the effect of HDACs on C/EB