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Regulation of interleukin 6 production by cAMP-protein kinase-a pathway in rat cortical astrocytes

✍ Scribed by G. Schettini; M. Grimaldi; P. Navarra; G. Pozzoli; S. Reichlin; P. Preziosi

Book ID
119179190
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
901 KB
Volume
30
Category
Article
ISSN
1043-6618

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Regulation of cAMP levels by protein kin
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## Abstract Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13‐dibutyrate (PDbU). An IC50 for PDbU of 38Β±5 nM and 62Β±8 nM was observed in the isoproternol and forskolin response, respectively. Similarly, C6 culture