Regulation of in-vivo differentiation of myeloid leukemic cells by antigen-specific helper T lymphocytes
β Scribed by Joseph Lotem; Avraham Ben-Nun; Leo Sachs
- Book ID
- 113238710
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 383 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0145-2126
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Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the
## Abstract It is shown that a 5βday schedule of two injections per day of the myeloid differentiationβinducing protein MGIβ2 inhibited the __in vivo__ development of leukemia in SL and SJL/J mice with different syngeneic MGI^+^D^+^ clones of myeloid leukemic cells. With this schedule of treatment