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Control of in-vivo differentiation of myeloid leukemic cells— V. Regulation by response to antigen

✍ Scribed by Joseph Lotem; Leo Sachs


Book ID
113238377
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
515 KB
Volume
9
Category
Article
ISSN
0145-2126

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📜 SIMILAR VOLUMES


Control of in vivo differentiation of my
✍ Joseph Lotem; Leo Sachs 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 881 KB

## Abstract It is shown that a 5‐day schedule of two injections per day of the myeloid differentiation‐inducing protein MGI‐2 inhibited the __in vivo__ development of leukemia in SL and SJL/J mice with different syngeneic MGI^+^D^+^ clones of myeloid leukemic cells. With this schedule of treatment

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## Abstract A line of mouse myeloid leukemic cells in culture contained two types of clones. One type can be induced by the differentiation‐inducing protein MGI to undergo normal differentiation to mature macrophages and granulocytes (D^+^ clones), whereas the other type could not be induced to dif

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## Abstract There are three types of myeloid leukemic cells, IR^+^D^+^, IR^+^D^−^ and IR^−^D^−^. IR^+^D^+^ cells were induced to differentiate to granulocytes in mass culture in liquid medium by conditioned medium (CM) from cultures of lungs from mice injected with endotoxin. About 90% of the leuke

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## Abstract An enriched population of early myeloid cells has been obtained from normal mouse bone marrow by injection of mice with sodium caseinate and the removal of cells with C3 (EAC) rosettes by Ficoll‐Hypaque density centrifugation. This enriched population had no EAC or Fc (EA) rosettes and