Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a
Regulation of IGF2 transcript and protein expression by altered methylation in breast cancer
β Scribed by Preetha J. Shetty; Sireesha Movva; Nagarjuna Pasupuleti; Bhavani Vedicherlla; Kiran K. Vattam; Sambasivan Venkatasubramanian; Yog R. Ahuja; Qurratulain Hasan
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 333 KB
- Volume
- 137
- Category
- Article
- ISSN
- 1432-1335
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The histological characteristics of phyllodes tumours of the breast are often not related to their clinical outcome. Additional studies must therefore be performed to investigate the possible relationship of cell biological parameters to the biological behaviour of these tumours. The expression of K
pS2 gene has been used to investigate the relationship between alterations of DNA methylation patterns in human tumors and gene expression. The expression of pS2, which is transcriptionally controlled by estrogens in breast cancer cell lines, is restricted to estrogen-receptor-rich human breast tumo