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Regulation of Hypoxia-Inducible Factor 2 Signaling by the Stress-Responsive Deacetylase Sirtuin 1

✍ Scribed by Dioum, E. M.; Chen, R.; Alexander, M. S.; Zhang, Q.; Hogg, R. T.; Gerard, R. D.; Garcia, J. A.

Book ID
126807764
Publisher
American Association for the Advancement of Science
Year
2009
Tongue
English
Weight
739 KB
Volume
324
Category
Article
ISSN
0036-8075

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## ABSTRACT Cigarette smoking is strongly implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mucus hypersecretion is the key manifestation in patients with COPD and mucin 5AC (MUC5AC) is a major component of airway mucus. Hypoxia inducible factor‐1 (HIF‐1) is a transcri