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Regulation of human methionine adenosyltransferase 2A expression by NFkB and AP-1

โœ Scribed by Yang, Heping; Yu, Victor; Zeng, Ying; Sadda, Mamatha; Lee, Taunia D.; Ou, Xiaopeng; Chen, Lixin; Haque, Masudul; Lu, Shelly C.


Book ID
122689763
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
256 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract Two genes (__MAT1A__ and __MAT2A__) encode for the essential enzyme methionine adenosyltransferase (MAT). __MAT1A__ is silenced in hepatocellular carcinoma (HCC), and absence of __MAT1A__ leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to