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Regulation of human glucocorticoid receptor gene transcription by Sp1 and p53

✍ Scribed by Tadashi Suehiro; Tadafumi Kaneda; Yukio Ikeda; Kaoru Arii; Yoshitaka Kumon; Kozo Hashimoto

Book ID
116733571
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
227 KB
Volume
222
Category
Article
ISSN
0303-7207

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## Abstract The tumor suppressor, p53, has been shown to transcriptionally activate or silence a number of target genes. As an activator, p53 relies on its specific consensus sequence within the promoter. It is not clear whether p53 requires a specific DNA binding site in its action as a gene repre