Regulation of human estrogen receptor α-mediated gene transactivation in Saccharomyces cerevisiae by human coactivator and corepressor proteins
✍ Scribed by Grant A. Bitter
- Book ID
- 116697883
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 527 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0960-0760
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This study demonstrates that the isolated regulatory (R) domain (amino acids 1 -270) of human protein kinase C a (PKCa) is a potent inhibitor of PKCP-I activity in a yeast expression system. The PKCa R domain fused to glutathione-S-transferase competitively inhibited the activity of yeast-expressed
## Abstract Estrogen (17β‐estradiol, E2) plays pivotal roles in the function and maintenance of the skeleton, including the bone‐forming osteoblasts (OBs). The functions of E2 are largely mediated through two distinct estrogen receptor isoforms, ERα and ERβ, both of which are expressed in OBs. The