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Potentiation of human estrogen receptor α-mediated gene expression by steroid receptor coactivator-1 (SRC-1) in Saccharomyces cerevisiae

✍ Scribed by Aaron R Ellison; Joan Lofing; Grant A Bitter

Book ID
117668597
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
162 KB
Volume
86
Category
Article
ISSN
0960-0760

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This report describes an investigation of the role of 1,25-dihydroxyvitamin D (VD 3 ) in the regulation of estrogen receptor-␣ (ER) in the ER-positive breast cancer cell line, MCF-7. Treatment of cells with 10 nM VD 3 resulted in a 50% decline in the concentration of ER protein at 24 h. Scatchard an