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Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: In vitro inhibition by a protein present in bile

✍ Scribed by Donald J. McNamara; Victor W. Rodwell

Book ID: 115702574
Publisher: Elsevier Science
Year: 1975
Tongue: English
Weight: 683 KB
Volume: 168
Category: Article
ISSN: 0003-9861
DOI: 10.1016/0003-9861(75)90266-0

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## Abstract Elevated 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase expression supports synthesis of prenyl pyrophosphate intermediates required for tumor growth. In this study, the copy number of HMG‐CoA reductase mRNA was determined in solid tumor and leukemic cell lines using competit