Regulation of granulopoiesis and distribution of granulocytes in early phase of bacterial infection

✍ Scribed by D. W. Hartmann; M. A. Entringer; W. A. Robinson; M. L. Vasil; C. J. Drebing; N. J. Morton; L. Ture

• Book ID: 102880036
• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 659 KB
• Volume: 109
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041090103

✦ Synopsis

Abstract

Studies have been carried out to determine the effect of bacterial infection on CSF production, CFU‐C activation, and bacterial clearance by mature granulocytes in mice infected with Escherichia coli. These studies have shown that immediately after bacterial infection (5 minutes), serum colony‐stimulating factor (CSF) levels and bone marrow colony‐forming units in culture (CFU‐C) levels are elevated. This is followed by oscillator rises in both of these parameters and the appearance of granulocytes in the infected site. With clearance of bacteria, CSF and CFU‐C levels return to normal. These studies have indicated further that bacterial infection is a major stimulus for granulocyte production through the CSF‐CFU‐C system and that clearance of bacteria by mature granulocytes may serve as a negative feedback regulatory arm.