New synthetic chemical inducers of dimerization, comprising homodimeric FKBP ligands with engineered specificity for the designed point mutant F36V, have been evaluated for inducing targeted gene expression in mammalian cells. Structure-activity studies indicated that high-affinity dimerizers such a
β¦ LIBER β¦
Regulation of Gene Expression by Synthetic DNA-Binding Ligands
β Scribed by Dervan, Peter B. ;Poulin-Kerstien, Adam T. ;Fechter, Eric J. ;Edelson, Benjamin S.
- Book ID
- 118192822
- Publisher
- Springer Berlin Heidelberg
- Year
- 2005
- Weight
- 1013 KB
- Category
- Article
- DOI
- 10.1007/b100440
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