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Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes

✍ Scribed by Carine Michiels; Emmanuel Minet; Denis Mottet; Martine Raes

Book ID
114275322
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
307 KB
Volume
33
Category
Article
ISSN
0891-5849

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## Abstract Large osteoclasts (10+ nuclei), predominant in rheumatoid arthritis and periodontal disease, have higher expression of proteases and activating receptors and also have increased resorptive activity when compared to small (2–5 nuclei) osteoclasts. We hypothesized that large and small ost