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Regulation of Fatty Acid Synthase Expression by Cholesterol in Human Cultured Cells

โœ Scribed by Yoshiki Kawabe; Ryuichiro Sato; Akiyo Matsumoto; Makoto Honda; Yoichiro Wada; Yoshio Yazaki; Akira Endo; Tatsuya Takano; Hiroshige Itakura; Tatsuhiko Kodama


Book ID
115578052
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
75 KB
Volume
219
Category
Article
ISSN
0006-291X

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The effects of pancreatic hormones and cyclic AMP on long-chain fatty-acid metabolism were investigated in human hepatocytes isolated from 12 liver biopsy specimens and cultured for 4 days in an insulin-free medium. Glucagon (10(-6) mol/L) increased endogenous ketone body production by 150%. This re