✦ LIBER ✦

Regulation of expression of plasminogen activator inhibitor-1 in cultured rat osteoblastic cells by osteogenic protein-1 (BMP-7)

✍ Scribed by Lee-Chuan C. Yeh; Valery Mikhailov; John C. Lee

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 204 KB
Volume: 81
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.1071

No coin nor oath required. For personal study only.

✦ Synopsis

Osteogenic Protein-1 (OP-1), a member of the bone morphogenetic protein (BMP) family that belongs to the TGF-b superfamily, induces bone formation in vivo and stimulates the synthesis of biochemical markers characteristic of osteoblast phenotypes in vitro. In the present study, effects of OP-1 on the expression of the plasminogen activator inhibitor-1 (PAI-1) in fetal rat calvaria (FRC) cells were examined. The PAI-1 protein levels in conditioned media of FRC cells treated with OP-1 or solvent control were determined by quantitative 2-dimensional polyacrylamide gel electrophoresis.

📜 SIMILAR VOLUMES

Endothelin-1 expression in long-term cul

Endothelin-1 expression in long-term cultures of fetal rat calvarial osteoblasts: Regulation by BMP-7

✍ Allison M. Kitten; Carrie J. Andrews 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

## Abstract Endothelin‐1 (ET‐1) is a vasoactive peptide that modulates bone metabolism via regulatory effects on osteoblasts, chondrocytes, and osteoclasts. While ET‐1 may circulate in the blood stream, tissue‐specific expression of this peptide is more physiologically relevant. In the present stud

Osteogenic protein-1 differentially regu

Osteogenic protein-1 differentially regulates the mRNA expression of bone morphogenetic proteins and their receptors in primary cultures of osteoblasts

✍ L.-C.C. Yeh; R. Unda; J.C. Lee 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB 👁 2 views

Regulation of plasminogen activator inhi

Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: Role of protein kinase Cα

✍ Chih-Chang Yeh; Hsin-I Chang; Jui-Kun Chiang; Wang-Ting Tsai; Li-Ming Chen; Chea 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB 👁 2 views

Control of the tissue inhibitor of metal

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: Regulation by activator protein-1 DNA binding proteins

✍ Matthias J. Bahr; Karen J. Vincent; Michael J. P. Arthur; Andrew V. Fowler; Davi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB 👁 2 views

Growth state-dependent regulation of pla

Growth state-dependent regulation of plasminogen activator inhibitor type-1 gene expression during epithelial cell stimulation by serum and transforming growth factor-β1

✍ Jeffrey R. Boehm; Stacie M. Kutz; E. Helene Sage; Lisa Staiano-Coico; Paul J. Hi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB 👁 1 views

Transit of serumstimulated normal rat kidney (NRK) epthelial cells through the first division cycle after release from quiescence (G 0 ) provided a model system to assess the kinetics and mechanisms underlying PAI-1 expression in a growth "activated" phenotype. PAI-1 mRNA transcripts increased by mo

β1 integrins mediate cell proliferation

β1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1

✍ Hira Lal Goel; Jean M. Underwood; Jeffrey A. Nickerson; Chung-Cheng Hsieh; Lucia 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB

## Abstract The β1 integrins play an important role in the modulation of cancer cell proliferation and tumor growth. We have previously shown that β1 integrins associate with insulin‐like growth factor type 1 receptor (IGF‐IR) and regulate IGF‐stimulated prostate cancer cell proliferation. In the p