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Regulation of estrogen receptor levels by ligand-induced release of compound(s) in MCF-7 cells

โœ Scribed by Hye-Sook Seo; Denis Larsimont; Yan Ma; Ioanna Laios; Guy Leclercq

Book ID
117462462
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
268 KB
Volume
164
Category
Article
ISSN
0303-7207

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โœ Adriana Stoica; Miguel Saceda; Amina Fakhro; Harrison B. Solomon; Bradley D. Fen ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 205 KB ๐Ÿ‘ 1 views

This report describes an investigation of the role of 1,25-dihydroxyvitamin D (VD 3 ) in the regulation of estrogen receptor-โฃ (ER) in the ER-positive breast cancer cell line, MCF-7. Treatment of cells with 10 nM VD 3 resulted in a 50% decline in the concentration of ER protein at 24 h. Scatchard an