Bone is the most frequent site of metastasis in breast cancer. This causes destructive osteolytic lesions. To achieve metastasis to bone, breast cancer cells must proliferate in a new microenvironment, arrest on extracellular matrix and invade. Breast cancer cells progress in the invasive processes
Regulation of estrogen sulfotransferase by estrogen in MCF-7 human mammary cancer cells
β Scribed by John B. Adams; Robertos Vrahimis; Narelle Phillips
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 495 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0167-6806
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Data from immunocytochemical assessment of estrogen receptor (ER) regulation in MCF-7 cells under estrogenic and anti-estrogenic stimulation were compared with those obtained by enzyme immunoassay (Abbott ER-EIA). Similar trends were observed, although ER level variations were less marked when asses
This report describes an investigation of the role of 1,25-dihydroxyvitamin D (VD 3 ) in the regulation of estrogen receptor-β£ (ER) in the ER-positive breast cancer cell line, MCF-7. Treatment of cells with 10 nM VD 3 resulted in a 50% decline in the concentration of ER protein at 24 h. Scatchard an