Regulation of ES cell differentiation by functional and conformational modulation of p53
โ Scribed by Sabapathy, K.
- Book ID
- 111745089
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 663 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0261-4189
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The transcription factor p53 controls the proliferation and survival of cells exposed to DNA damage. The specific DNA-binding domain of p53 (residues 102-292) has a complex tertiary structure that is stabilized by zinc. In this study, we showed that exposure of cultured cells to the membrane-permeab
## Abstract The tumor suppressor p53 is frequently mutated in cancer. We have investigated the regulation of P53 in p53 wild type mouse hepatoma cells (line 55.1c), in p53 heterozygeously mutated cells (56.1b) and in p53 defective cells (lines 56.1d, 70.4 and HUH7) under various experimental settin