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Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

✍ Scribed by G. Smith; S.H. Ibbotson; M.M. Comrie; R.S. Dawe; A. Bryden; J. Ferguson; C.R. Wolf

Book ID: 108668876
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 175 KB
Volume: 155
Category: Article
ISSN: 0007-0963
DOI: 10.1111/j.1365-2133.2006.07317.x

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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev